Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Spectrophotometric Determination of Cilostazol in Tablet Dosage Form

Pawan Kumar Basniwal¹ , Vinesh Kumar¹, Prabhat Kumar Shrivastava², Deepti Jain³

¹LBS College of Pharmacy, Tilak Nagar, Jaipur - 302004, Rajasthan; ²Department of Pharmaceutics, Banaras Hindu University, Banaras, UP; ³School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Bhopal (MP), India.

For correspondence:- Pawan Basniwal Email: pawanbasniwal@gmail.com Tel:+919414788171

Received: 8 January 2010 Accepted: 21 July 2010 Published: 17 October 2010

Citation: Basniwal PK, Kumar V, Shrivastava PK, Jain D. Spectrophotometric Determination of Cilostazol in Tablet Dosage Form. Trop J Pharm Res 2010; 9(5):499-503 doi: 10.4314/tjpr.v9i5.11

© 2010 The authors.
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Abstract

Purpose: To develop simple, rapid and selective spectrophotometric methods for the determination of cilostazol in tablet dosage form.

Methods: Cilostazol was dissolved in 50 % methanol and its absorbance was scanned by ultraviolet (UV) spectrophotometry. Both linear regression equation and standard absorptivity were calculated and both methods were validated as per ICH guidelines. Cilostazol was determined in tablet dosage form using these validated methods.

Results: The l_max of cilostazol was 258.2 nm in 50 % methanol. Beer-Lambert’s law was obeyed in the concentration range of 0 – 25 mg/ml and standard absorptivity was 420.2 dL.g^-1.cm^-1_.The numerical values for all the validation parameters were within acceptable limits. The results of cilostazol tablet determination by linear regression equation and standard absorptivity methods indicate purity of 100.0 - 102.4 and 98.7 - 101.1 % with standard deviations of 0.611 and 0.592, respectively. Comparing the methods at 99 % confidence limit, the F-test value was found to be 1.065.

Conclusion: These validated methods may be useful for routine analysis of cilostazol as bulk drugs, in dosage forms as well as in dissolution studies in the pharmaceutical industry.

Keywords: Cilostazol tablets, UV spectrophotometry, Linear regression equation, Standard absorptivity